Vardenafil protects against myocardial and endothelial injuries after cardiopulmonary bypass☆
نویسندگان
چکیده
منابع مشابه
The endothelial glycocalyx protects against myocardial edema.
Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent studies suggest that carbohydrate structures on the luminal surface of microvascular endothelium are essential to prevent tissue edema. We carefully preserved these structures for visualization with elec...
متن کاملEndothelial apoptosis and circulating endothelial cells after bypass grafting with and without cardiopulmonary bypass.
OBJECTIVE We compared profiles of the numbers of circulating endothelial cells (CEC) and the apoptosis-inducing capacity of serum samples on human endothelial cells (hEC) in on-pump and off-pump coronary artery bypass grafting (CABG) patients. METHODS Blood samples from 30 patients undergoing CABG (randomly assigned to two groups: 15 patients off-pump and 15 on-pump (cardiopulmonary bypass, C...
متن کاملEndothelial Glycocalyx and Cardiopulmonary Bypass.
On the outer surface of a human cell there is a dense layer of complex carbohydrates called glycocalyx, also referred to as glycans or the sugar coating on the cell surface, which is composed of a complex array of oligosaccharide and polysaccharide glucose chains that are covalently bonded to proteoglycans and lipids bound to the cell membrane surface. Studies of an intact endothelial glycocaly...
متن کاملMyocardial histology and outcome after cardiopulmonary bypass of neonatal piglets.
BACKGROUND Early after neonatal cardiac surgery hemodynamic dysfunction may be evident. However, still is not clear if dysfunction and outcome is related to visible myocardial alterations. The aim of the present study was the histological analysis of myocardial tissue of neonatal piglets after cardiopulmonary bypass (CPB) and cardioplegic arrest. METHODS Neonatal piglets (younger than 7 days)...
متن کاملSelective endothelial dysfunction in conscious dogs after cardiopulmonary bypass.
It has previously been demonstrated that cardiopulmonary bypass (CPB) causes prolonged pulmonary vascular hyperreactivity (D.P. Nyhan, J.M. Redmond, A.M. Gillinov, K. Nishiwaki, and P.A. Murray. J. Appl. Physiol. 77: 1584-1590, 1994). This study investigated the effects of CPB on endothelium-dependent (acetylcholine and bradykinin) and endothelium-independent (sodium nitroprusside) pulmonary va...
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ژورنال
عنوان ژورنال: European Journal of Cardio-Thoracic Surgery
سال: 2009
ISSN: 1010-7940
DOI: 10.1016/j.ejcts.2009.03.065